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HYDREA is a cytotoxic drugFollow applicable special handling and disposal proceduressee REFERENCES

It is important to make sure you are taking the correct amount of medication every timeBefore every dosecheck that what you are taking matches what you have been prescribed.

Cutaneous vasculitic toxicitiesincluding vasculitic ulcerations and gangrenehave occurred in patients with myeloproliferative disorders during therapy with hydroxyureaThese vasculitic toxicities were reported most often in patients with a history ofor currently receivinginterferon therapyIf cutaneous vasculitic ulcers occurinstitute treatment and discontinue HYDREA.

Antineoplastic agents exert their benefits by killing rapidly growing cancer cellsUse of medications that stimulate cell growth is usually not recommended in patients who have been exposed to cytotoxic chemotherapy within 24 hoursSpecificallythe manufacturer of pegfilgrastimNeulastarecommends that pegfilgrastim should not be administered to patients who have been treated with cytotoxic chemotherapy within the prior 14 daysAlsochemotherapy should not be administered within 24 hours of pegfilgrastim.

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